Project #79017 - Protein Function

Explain two differences between the oxygenated and deoxygenated states of hemoglobin. 

 

This was my response:Hemoglobin can bind to four molecules of oxygen. This binding is cooperative. When Hemoglobin molecules bind to oxygen, molecules they are referred to as oxygenated hemoglobin (Harvey, et al., 2011). Hemoglobins that are not bound to oxygen molecules are referred to as deoxygenated molecules. The other difference between the two forms of hemoglobin is that the helix structure and the proximal histidine of oxygenated hemoglobin shifts. Existing noncovalent bonds in deoxygenated hemoglobin are broken and replaced with new ones upon oxygenation (Jones, 2008). Oxygenated hemoglobin binds with the heme protein in hemoglobin and is formed through the transportation of oxygen to cells in tissues; meanwhile, deoxygenated hemoglobin is NOT bound and has a higher absorption. In deoxygenated hemoglobin, the interactions between the two heterodimers are stronger in the (T)ense state. These same interactions however, are now weaker in the (R)elaxed state of an oxygenated hemoglobin. 

 

This is from the graders, I don't know what I'm doing/listing wrong:08/11/15 - The report accurately defines oxygenated and deoxygenated hemoglobin, and partially explains the difference between oxygenated and deoxygenated states of hemoglobin, including, the tense state of deoxygenated hemoglobin compared to the relaxed state of oxygenated hemoglobin. The discussion thoughtfully notes that oxygen binding to hemoglobin is cooperative. Specific details explaining what is meant by cooperative and its relationship to oxygenated and deoxygenated hemoglobin is not readily apparent. One more difference between oxygenated and deoxygenated hemoglobin is not readily apparent. 08/10/15 - The response diligently defines oxygenated and deoxygenated hemoglobin, and references a structural change that occurs as oxygen is bound. A logical, detailed explanation of two differences between the oxygenated and deoxygenated states of hemoglobin is not found.

Subject Science
Due By (Pacific Time) 08/11/2015 10:56 am
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